Systemic Lupus Erythematosus

Summarized by Plex Health
Last Updated: 02 May 2022
regulatory t cells in systemic lupus erythematosus: past, present and future. "regulatory t cells in systemic lupus erythematosus: past, present and future.", by Horwitz DA. F1: T-cell/dendritic cell interactions in health and in systemic lupus erythematosus. Regulatory T cells (Tregs) (red) and effector T cells, shown as potentially pathogenic anti-self T cells (blue), can affect the maturation of immature dendritic...

Systemic lupus erythematosus is a chronic autoimmune disease that can impact many parts of the body. Lupus flares can be mild to significant, and they are unforeseeable. With treatment, many people with lupus can manage the disease. Anybody can get lupus; nonetheless, women get the disease about 9 times more frequently than men. Lupus is more common in African Americans than in white people and is more common in people of American Indian and Asian descent. If you have a member of the family with lupus or another autoimmune disease, you may be most likely to develop lupus. The symptoms of lupus vary from individual to person and can range from mild to serious. Symptoms may reoccur, and you may develop new symptoms with time. Lupus causes inflammation throughout the body, which can impact other areas of the body and lead to other problems, consisting of: Lupus nephritis, which causes kidney damages that can lead to changes in kidney function, consisting of kidney failure. Most affected individuals also have joint pain, normally impacting the same joints on both sides of the body, and muscular tissue pain and weakness. Other skin problems that may occur in SLE consist of calcium deposits under the skin, harmed blood vessels in the skin, and small red spots called petechiae. About a third of people with SLE develop kidney disease. Heart problems might also occur in SLE, consisting of swelling of the sac-like membrane layer around the heart and abnormalities of the heart shutoffs, which control blood flow in the heart. Heart problem brought on by fatty buildup in the blood vessels, which is very common in the basic population, is even more common in people with SLE. When it gets better, people with SLE have episodes in which the condition obtains worse and other times. People with SLE might experience a variety of symptoms that consist of tiredness, skin rashes, high temperatures, and pain or swelling in the joints. Other adults might experience SLE flares more regularly throughout their life. These constraints experienced by people with SLE can affect their quality of life, specifically if they experience tiredness. Many studies use work as a measure to determine the top quality of life of people with SLE, as employment is central to a person's life. Since SLE therapy may call for making use of solid immunosuppressive drugs that can have major side effects, female patients have to stop taking the medication prior to and during pregnancy to shield expected children from damage. Women with lupus can securely get pregnant and most will have healthy children and normal maternities. However all women with lupus who get pregnant are considered to have a high risk pregnancy.

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