Tafenoquine

Summarized by Plex Health
Last Updated: 02 May 2022
assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections. "assessment of the prophylactic activity and pharmacokinetic profile of oral tafenoquine compared to primaquine for inhibition of liver stage malaria infections.", by Li Q, O'Neil M, Xie L, Caridha D, Zeng Q, Zhang J, Pybus B, Hickman M, Melendez V. F2: Representative in vivo images (IVIS) of luminescence shown in the livers of live C57BL/6 albino mice at different time points after injection of 5 × 104sporozoites. Rainbow images show the relative levels of luminescence...

Tafenoquine is an anti-malaria medicine that conflicts with the growth of bloodsuckers in the body. You must additionally not nurse for at least 3 months after your last dosage of tafenoquine if the baby does have G6PD deficiency. Tafenoquine may hurt a coming infant. The usual dose of tafenoquine is 2 tablets taken at one time. Begin taking tafenoquine on the first or 2nd day you start taking chloroquine. Call your physician as soon as possible if you have been subjected to malaria, or if you have fever, vomiting, or looseness of the bowels during or after a remain in an area where malaria prevails. The structural formula of tafenoquine succinate is: Figure 1: Tafenoquine Succinate Structure. The chemical name of tafenoquine succinate is -8 [amino] -2,6-dimethoxy-4methyl-5 [3- phenoxy] quinoline succinate. The molecular formula of tafenoquine succinate is C24H28F3N3O3 C4H6O4 and its molecular weight is 581. 6 as the succinate salt. Each ARAKODA tablet computer consists of 100 mg of tafenoquine. Non-active ingredients consist of magnesium mannitol, microcrystalline, and stearate cellulose. The tablet film coating non-active components consist of: hypromellose, iron oxide red, macrogol/polyethylene glycol and titanium dioxide. Tafenoquine belongs to a group of medicines, called antiprotozoals. It works by dealing with malaria, a red blood cell infection transferred by the bite of an insect. It also avoids the growth of the blood forms of the bloodsucker, which are in charge of the relapse. This medicine is offered only with your physician's prescription.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
115358C24H28F3N3O3463.5CC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OCCC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OCInChI=1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3LBHLFPGPEGDCJG-UHFFFAOYSA-N4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine5.4463.20827625463.2082762578.659702993301010001
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