Tardive Dyskinesia

"gray matter abnormalities in schizophrenia patients with tardive dyskinesia: a magnetic resonance imaging voxel-based morphometry study.", by Li CT, Chou KH, Su TP, Huang CC, Chen MH, Bai YM, Lin CP. pone-0071034-g002: Regions of reduced gray matter volume in schizophrenia with tardive dyskinesia group compared with schizophrenia without tardive dyskinesia group....

Tardive dyskinesia is an involuntary neurological movement disorder triggered by using dopamine receptor blocking drugs that are suggested to treat particular psychological or gastrointestinal conditions. Long-term use these drugs might create biochemical irregularities in the area of the brain known as the striatum. The reasons that some people that take these drugs may get tardive dyskinesia, and some people do not, is unknown. Tardive dystonia is a more serious type of tardive dyskinesia in which slower turning movements of the neck and trunk muscle mass project. When you take medications called neuroleptics, td is a severe side effect that happens. TD usually takes place when you take the medication for many months or years. Chlorpromazine; Fluphenazine; Haloperidol; Perphenazine; Prochlorperazine; Thioridazine; Trifluoperazine; Newer antipsychotics seem less likely to cause TD, however they are not entirely without risk. Metoclopramide; Antidepressant medicines such as amitriptyline, fluoxetine, phenelzine, sertraline, trazodone; Anti-Parkinson medicines such as levodopa; Antiseizure medications such as phenobarbital and phenytoin; Facial grimacing; Finger movement; Rocking or propelling of the pelvis; Jaw swinging; Repetitive chewing; Rapid eye blinking; Tongue propelling; Restlessness; It is unclear why some people that take neuroleptic medications develop these symptoms while others do not.

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