Tolvaptan

Summarized by Plex Health
Last Updated: 02 May 2022
different effects of tolvaptan in patients with idiopathic membranous nephropathy with nephrotic syndrome "different effects of tolvaptan in patients with idiopathic membranous nephropathy with nephrotic syndrome", by . g002: A: Immunohistochemistry of AQP-2 (brown) in Case 1, a tolvaptan responder (magnified 100×). B: Immunohistochemistry of AQP-2 (brown) in Case 2, a tolvaptan non-responder (magnified 100×). The level of AQP-2 immunostaining was weaker than...

Jynarque is used to slow down the decline in kidney function in adults who have autosomal dominant polycystic kidney disease. Samsca boosts urine flow without creating the body to lose excessive salt as you pee. Tolvaptan may also be used for purposes not listed in this medicine overview. You additionally need to not use Jynarque if you have ever before had liver problems, or if your sodium blood degree is too low or too high. You might take tolvaptan with or without food. Long-lasting use of Samsca can damage your liver. Tolvaptan is -4'- [carbonyl] -otolu-mtoluidide. The empirical formula is C26H25ClN2O3. Molecular weight is 448. 94. The chemical framework is: Inactive components consist of corn starch, hydroxypropyl cellulose, lactose monohydrate, low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, and FD&C Blue No. 2 Aluminum Lake as colorant. Tolvaptan is also used to slow down kidney function decline in adults that go to risk of quickly progressing autosomal leading polycystic kidney disease. Sodium is a chemical that the body requires for it to function well. If you have a low salt blood level, your body will not function normally and you may not really feel well. Tolvaptan operates in the kidneys to help maintain the right amount of sodium for the body. Samsca is offered only with your medical professional's prescription. Jynarque is offered only under a limited circulation program called the Jynarque REMS Program.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
216237C26H25ClN2O3448.9CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)CCC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)CInChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)GYHCTFXIZSNGJT-UHFFFAOYSA-NN-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide4.8448.1553704448.155370469.667402333201010001
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