Topiramate

Summarized by Plex Health
Last Updated: 02 May 2022
topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. "topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.", by Gensel JC, Tovar CA, Bresnahan JC, Beattie MS. pone-0033519-g002: Topiramate treatment significantly increased NeuN+ neuron sparing 48-hrs after severe spinal cord injury.A–F) Representative examples of NeuN labeling ipsilateral to the side of injury 1 mm-caudal to lesion epicenter. Pictures are from around the...

Topiramate is a seizure medicine, also called an anticonvulsant. Some brand names of topiramate are also used to stop migraine headaches in adults and teens who are at least 12 years old. Some people have ideas about suicide while taking seizure medication. You might require blood tests to ensure you do not have metabolic acidosis, particularly if you are pregnant. Taking topiramate throughout pregnancy might increase the risk of slit lip and/or cleft taste, a birth flaw that can develop early in maternity even prior to you know you are pregnant. If you take topiramate during maternity: The benefit of stopping seizures might exceed any risks posed by topiramate. Topiramate can make contraceptive pill less reliable. Topiramate works by minimizing bursts of electric activity in your brain and recovering the normal balance of nerve activity. It can take 2 to 4 weeks to work completely if you're taking topiramate for epilepsy. Common side effects of topiramate consist of feeling drowsy, feeling woozy, diarrhoea and feeling sick. If you intend to change from topiramate to another medication, it's very important to follow your physician's advice. You'll need to begin taking the new one at a low dosage and gradually accumulate the dosage while you're still taking topiramate. If you have epilepsy, you're entitled to free prescriptions for every one of your medications, not just your epilepsy ones. Topiramate is most soluble in alkaline options including sodium hydroxide or salt phosphate and having a pH of 9 to 10. Topiramate is designated chemically as 2,3:4,5-Di-Oisopropylidene- Dfructopyranose sulfamate and has the complying with structural formula: Topiramate tablets consist of the adhering to non-active components: lactose monohydrate, microcrystalline cellulose, pre-gelatinized starch, hypromellose, salt starch glycolate, magnesium stearate, titanium dioxide, polyethylene glycol. The 50 mg stamina consists of polysorbate, iron oxide yellow and iron oxide red. FDA accepted tests Assay and associated substances vary from USP. FDA accepted dissolution test specs vary from USP.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5284627C12H21NO8S339.36CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)CCC1(O[[email protected]@H]2CO[[email protected]@]3([[email protected]]([[email protected]@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)CInChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1KJADKKWYZYXHBB-XBWDGYHZSA-N[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate-0.8339.09878780339.0987878012455601932204400001
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