Topotecan

Summarized by Plex Health
Last Updated: 02 May 2022
toxicogenomics profiling of bone marrow from rats treated with topotecan in combination with oxaliplatin: a mechanistic strategy to inform combination toxicity. "toxicogenomics profiling of bone marrow from rats treated with topotecan in combination with oxaliplatin: a mechanistic strategy to inform combination toxicity.", by Davis M, Li J, Knight E, Eldridge SR, Daniels KK, Bushel PR. F1: Representative images of bone marrow hypocellularity in femur from male rats 24 h after a single 30 min IV infusion dose of oxaliplatin, topotecan or combination of oxaliplatin followed by topotecan. Hematoxylin and eosin...

The chemical name for topotecan hydrochloride is -10- [methyl] -4 ethyl-4,9-dihydroxy-1H-pyrano [3',4':6,7] indolizino [1,2-b] quinoline-3,14-dione monohydrochloride. The molecular formula is C23H23N3O5HCl and the molecular weight is 457. 9 g/mol. It is soluble in water and melts with decomposition at 213 C to 218 C. Topotecan hydrochloride has the following structural formula: Topotecan Hydrochloride for Injection, for intravenous use is supplied as a clean and sterile, lyophilized, buffered, light yellow to greenish powder available in single-dose vials. Each vial contains 4 mg topotecan hydrochloride as free base. The reconstituted remedy ranges in shade from yellow to yellow-green. Inactive components are mannitol, 48 mg, and tartaric acid, 20 mg. Hydrochloric acid and sodium hydroxide might be used to adjust the pH. The service pH ranges from 2. 5 to 3. 5 Many patients with SCLC respond to an initial therapy with radiation treatment and/or immunotherapy. In an NCI-supported professional trial, the combination therapy reduced the tumors in 9 of 25 patients with SCLC whose cancer had slipped back after earlier treatment, according to outcomes published April 12 in Cancer Cell. NCI is carrying out a stage 2 randomized test that will compare the combination therapy with topotecan alone in patients with SCLC that has relapsed. A goal of the current research was to determine a combination of drugs that would include topotecan yet be more effective than topotecan alone. Most patients with SCLC have a very great preliminary response to a combination of radiation treatment and immune checkpoint inhibitors, stated Dr. Thomas. We think the tumor may have an innate capability to repair the DNA, which would describe the quick tumor relapses, stated Dr. Thomas. Inform your doctor or registered nurse right away if you have diarrhea after taking topotecan. The team might take blood samples to inspect topotecan degrees in the blood and to examine for changes in blood counts and liver function. If you have issues taking this medicine on an empty stomach, talk with your physician or pharmacist. Store the fluid medicine in the refrigerator. Do not take this medication if you are pregnant since topotecan might cause birth flaws. Both women and men that are taking topotecan must use effective birth control approaches. Women that are taking topotecan ought to not breast-feed an infant due to the fact that this medicine might cause severe harm to a nursing infant. All chemotherapy drugs taken by mouth can post a wellness threat to caretakers and patients. If your skin comes in contact with the medication, Wash your hands right away.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
60700C23H23N3O5421.4CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)OCC[[email protected]@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)OInChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1UCFGDBYHRUNTLO-QHCPKHFHSA-N(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione0.5421.16377084421.1637708410386702733101100001
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