Tumor necrosis factor receptor-associated periodic syndrome is a problem identified by recurrent episodes of fever. Some people can go many years without having a fever episode. During episodes of fever, people with TRAPS can have extra symptoms and signs. Affected individuals might additionally experience puffiness or swelling in the skin around the eyes; joint pain; and swelling in different areas of the body including the eyes, heart muscular tissue, certain joints, throat, or mucous membrane layers such as the damp cellular lining of the mouth and digestion system. Occasionally, people with TRAPS develop amyloidosis, an abnormal accumulation of a protein called amyloid in the kidneys that can lead to kidney failure. It is approximated that 15 to 20 percent of people with TRAPS develop amyloidosis, commonly in mid-adulthood. The fever episodes particular of TRAPS can begin at any age, from early stage to late adulthood, but the majority of people have their first episode in youth.
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