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Summarized by Plex Health
Last Updated: 01 May 2022
th17 cells and activated dendritic cells are increased in vitiligo lesions. "th17 cells and activated dendritic cells are increased in vitiligo lesions.", by Wang CQ, Cruz-Inigo AE, Fuentes-Duculan J, Moussai D, Gulati N, Sullivan-Whalen M, Gilleaudeau P, Cohen JA, Krueger JG. pone-0018907-g003: NALP-1 positive Langerhans cells are found in lesional vitiligo skin.Immunohistochemical staining of NALP-1 on vitiligo biopsies and double staining of NALP-1 with CD207 and HLA-DR on lesional skin. (A) Immunohistochemical staining shows higher numbers...

Vitiligo is a condition that causes uneven loss of skin coloring. Additionally, hair on these regions of skin can lose pigment and appear white. Another type of the problem, called segmental vitiligo, is related to smaller spots of depigmented skin that appear on one side of the body in a limited area. In people with vitiligo the immune system appears to attack the pigment cells in the skin. About 15 to 25 percent of people with vitiligo are also affected by a minimum of one other autoimmune disorder, particularly autoimmune thyroid disease, rheumatoid arthritis, type 1 diabetes, psoriasis, destructive anemia, Addison disease, systemic lupus erythematosus, gastric disease, Crohn disease, or ulcerative colitis. The pale areas of skin are more at risk to sunburn, so it's essential to take added treatment when in the sun and use a sunscreen with a high sun defense variable. The areas of skin most frequently affected by vitiligo include: mouth and eyes; fingers and wrists; underarms; groin; genitals; inside your mouth. The lack of melanin in your skin can transform the hair in the affected area grey or white. If there are blood vessels under the skin, the spot may be slightly pink, as opposed to white. Some people only get a couple of small, white spots, yet others get larger white patches that join up throughout large areas of their skin. Some people have loss of pigment in patches of hair on the head or body. Vitiligo has a tendency to proceed with time, triggering larger areas of skin to lose pigment. Lots of people with vitiligo also have a personal or family background of autoimmune disease, suggesting that vitiligo has an autoimmune cause. People with vitiligo usually report that its beginning was connected to a specific causing event, such as injury, illness, sunburn, psychological stress, or maternity. Vitiligo often "runs in families," suggesting a hereditary basis.

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