Vorinostat is used to treat skin issues brought on by cutaneous T-cell lymphoma. The empirical formula is C14H20N2O3. The molecular weight is 264. 32 and the structural formula is: Vorinostat is a white to light orange powder. It is very a little soluble in water, somewhat soluble in isopropanol, ethanol and acetone, freely soluble in dimethyl sulfoxide and insoluble in methylene chloride. It has no chiral facilities and is non-hygroscopic. The differential scanning calorimetry varied from 161. 7 to 163. 9 C. The pH of saturated water remedies of vorinostat medicine substance was 6. 6 The pKa of vorinostat was identified to be 9. 2 Each 100 mg ZOLINZA capsule for oral administration consists of 100 mg vorinostat and the following non-active ingredients: microcrystalline cellulose, salt croscarmellose and magnesium stearate. The pill shell excipients are titanium dioxide, jelly and sodium lauryl sulfate.
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