Vorinostat
Summarized by Plex Health
Last Updated: 03 May 2022
Vorinostat is used to treat skin issues brought on by cutaneous T-cell lymphoma. The empirical formula is C14H20N2O3. The molecular weight is 264. 32 and the structural formula is: Vorinostat is a white to light orange powder. It is very a little soluble in water, somewhat soluble in isopropanol, ethanol and acetone, freely soluble in dimethyl sulfoxide and insoluble in methylene chloride. It has no chiral facilities and is non-hygroscopic. The differential scanning calorimetry varied from 161. 7 to 163. 9 C. The pH of saturated water remedies of vorinostat medicine substance was 6. 6 The pKa of vorinostat was identified to be 9. 2 Each 100 mg ZOLINZA capsule for oral administration consists of 100 mg vorinostat and the following non-active ingredients: microcrystalline cellulose, salt croscarmellose and magnesium stearate. The pill shell excipients are titanium dioxide, jelly and sodium lauryl sulfate.
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Sources:
https://www.drugs.com/mtm/vorinostat.html
https://www.cancer.gov/about-cancer/treatment/drugs/vorinostat
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd86ee78-2781-468b-930c-3c4677bcc...
Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5311 | C14H20N2O3 | 264.32 | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO | InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) | WAEXFXRVDQXREF-UHFFFAOYSA-N | N'-hydroxy-N-phenyloctanediamide | 1.9 | 264.14739250 | 264.14739250 | 78.4 | 276 | 0 | 3 | 3 | 8 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
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